|
KMID : 0381120220440060659
|
|
Genes and Genomics
2022 Volume.44 No. 6 p.659 ~ p.670
|
|
|
Prognostic significance of three endothelial nitric oxide synthase (eNOS) polymorphisms and metabolic syndrome (MetS) in patients with colorectal cancer
|
|
Ko Eun-Ju
Kim Eo-Jin
Cho Hye-Jung
Oh Ji-Su
Park Han-Sung
Ryu Chang-Soo
Kim Jung-Oh
Jun Hak-Hoon
Chong So-Young
Kim Jong-Woo
Kim Nam-Keun
|
|
|
Abstract
|
|
|
Background: Polymorphisms of endothelial nitric oxide synthases (eNOS) have been associated with cancer susceptibility. Also, metabolic syndrome is associated with cancer malignancy. However, the effect of eNOS polymorphisms and metabolic syndrome on colorectal cancer (CRC) prognosis remains unclear.
Objective: To investigated whether three genetic polymorphisms (? 786 T?>?C rs2070744, 4a4b rs869109213, and 894G?>?T rs1799983) in the eNOS and metabolic syndrome (MetS) were associated with CRC patient survival.
Methods: We genotyped three polymorphisms of eNOS (? 786 T?>?C, 4a4b, and 894G?>?T) in 312 CRC cases from the Korean population by polymerase chain reaction-restriction fragment length polymorphism (PCR?RFLP) analysis.
Results: Although the three eNOS polymorphisms were not causative of MetS, the TT genotype of the 894G?>?T polymorphism was associated with a worse survival rate compared with the GG genotype in the CRC group with MetS than in the CRC group without MetS (5-years survival; adjusted HR?=?54.777; 95% CI 5.073?591.487 and RFS; adjusted HR?=?14.909; 95% CI 1.571?141.528).
Conclusions: The eNOS polymorphisms were not associated with metabolic syndrome prevalence in CRC patients. However, our findings suggest that the eNOS 894G?>?T polymorphism with MetS was associated with poor clinical outcomes.
|
|
|
KEYWORD
|
|
|
eNOS, Polymorphism, Metabolic syndrome, Colorectal cancer, Susceptibility, Nitric oxide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|